General Information

  • ID:  hor000817
  • Uniprot ID:  B3EWM1
  • Protein name:  Corazonin
  • Gene name:  NA
  • Organism:  Delia radicum (Cabbage root fly) (Anthomyia brassicae)
  • Family:  Corazonin family
  • Source:  animal
  • Expression:  Detected in larvae and adults. |In larvae, both corazonin and corazonin(3-11) are expressed in the CNS but not the midgut or thoracic perisympathetic organs (tPSO) and abdominal perisympathetic organs (aPSO). Corazonin is expressed in the ring gland (at p
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Delia (genus), Anthomyiinae (subfamily), Anthomyiidae (family), Muscoidea (superfamily), Calyptratae, Schizophora, Cyclorrhapha, Eremoneura, Muscomorpha (infraorder), Brachycera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QTFQYSRGWTN
  • Length:  11(1-11)
  • Propeptide:  QTFQYSRGWTN
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid;T11 Asparagine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Be involved in the physiological regulation of the heart beat
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000817_AF2.pdbhor000817_ESM.pdb

Physical Information

Mass: 156601 Formula: C62H86N18O19
Absent amino acids: ACDEHIKLMPV Common amino acids: QT
pI: 9.35 Basic residues: 1
Polar residues: 6 Hydrophobic residues: 2
Hydrophobicity: -154.55 Boman Index: -3507
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 0
Instability Index: 713.64 Extinction Coefficient cystines: 6990
Absorbance 280nm: 699

Literature

  • PubMed ID:  20869420
  • Title:  Neuropeptides Associated With the Central Nervous System of the Cabbage Root Fly, Delia Radicum (L)